Chronic doxorubicin administration impacts satellite cell and capillary abundance in a muscle-specific manner.

ABSTRACT: Anthracycline chemotherapies are effective at reducing disease recurrence and mortality in cancer patients. However, these drugs also contribute to skeletal muscle wasting and dysfunction. The purpose of this study was to assess the impact of chronic doxorubicin (DOX) administration on satellite cell and capillary densities in different skeletal muscles. We hypothesized that DOX would reduce satellite cell and capillary densities of the soleus (SOL) and extensor digitorum longus (EDL) muscles, along with muscle fiber size. Ovariectomized female Sprague-Dawley rats were randomized to receive three bi-weekly intraperitoneal injections of DOX (4 mg∙kg^-1 ; cumulative dose 12 mg∙kg^-1 ) or vehicle (VEH; saline). Animals were euthanized 5d following the last injection and th

SUBMITTER: D'Lugos AC 

PROVIDER: S-EPMC6453819 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature