Factors predicting long-term comorbidities in patients with Cushing's syndrome in remission.

ABSTRACT:

Purpose

In Cushing's syndrome, comorbidities often persist after remission of glucocorticoid excess. Here, we aim to identify factors predicting long-term comorbidities in patients with Cushing's syndrome in remission.

Methods

In a retrospective cross-sectional study, 118 patients with Cushing's syndrome in remission (52 pituitary, 58 adrenal, 8 ectopic) were followed for a median of 7.9 years (range 2-38) after the last surgery. Associations between baseline anthropometric, metabolic, hormonal parameters at diagnosis, and comorbidities (obesity, diabetes, hyperlipidemia, hypertension, osteoporosis, depression) at last follow-up, were tested by uni- and multivariate regression analysis.

Results

In patients with manifest comorbidities at diagnosis, remission of Cushing

SUBMITTER: Schernthaner-Reiter MH 

PROVIDER: S-EPMC6453862 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature