Pulse Arrival Time and Pulse Interval as Accurate Markers to Detect Mechanical Alternans.

ABSTRACT: Mechanical alternans (MA) is a powerful predictor of adverse prognosis in patients with heart failure and cardiomyopathy, but its use remains limited due to the need of invasive continuous arterial pressure recordings. This study aims to assess novel cardiovascular correlates of MA in the intact human heart to facilitate affordable and non-invasive detection of MA and advance our understanding of the underlying pathophysiology. Arterial pressure, respiration, and ECG were recorded in 12 subjects with healthy ventricles during voluntarily controlled breathing at different respiratory rate, before and after administration of beta-blockers. MA was induced by ventricular pacing. A total of 67 recordings lasting approximately 90 s each were analyzed. Mechanical alternans (MA) was measured in th

SUBMITTER: van Duijvenboden S 

PROVIDER: S-EPMC6453876 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature