Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age.

ABSTRACT: In advanced age, some individuals maintain a stable cognitive trajectory while others experience a rapid decline. Such variation in cognitive trajectory is only partially explained by traditional neurodegenerative pathologies. Hence, to identify new processes underlying variation in cognitive trajectory, we perform an unbiased proteome-wide association study of cognitive trajectory in a discovery (n = 104) and replication cohort (n = 39) of initially cognitively unimpaired, longitudinally assessed older-adult brain donors. We find 579 proteins associated with cognitive trajectory after meta-analysis. Notably, we present evidence for increased neuronal mitochondrial activities in cognitive stability regardless of the burden of traditional neuropathologies. Furthermore, we provide additional

SUBMITTER: Wingo AP 

PROVIDER: S-EPMC6453881 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature