Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.

ABSTRACT: Bacterial degradation of organosulfonates plays an important role in sulfur recycling, and has been extensively studied. However, this process in anaerobic bacteria especially gut bacteria is little known despite of its potential significant impact on human health with the production of toxic H₂S. Here, we describe the structural and biochemical characterization of an oxygen-sensitive enzyme that catalyzes the radical-mediated C-S bond cleavage of isethionate to form sulfite and acetaldehyde. We demonstrate its involvement in pathways that enables C2 sulfonates to be used as terminal electron acceptors for anaerobic respiration in sulfate- and sulfite-reducing bacteria. Furthermore, it plays a key role in converting bile salt-derived taurine into H₂S in the disease-as

SUBMITTER: Xing M 

PROVIDER: S-EPMC6453916 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature