Ability of bifidobacteria to metabolize chitin-glucan and its impact on the gut microbiota.

ABSTRACT: Chitin-glucan (CG) represents a natural carbohydrate source for certain microbial inhabitants of the human gut and may act as a prebiotic for a number of bacterial taxa. However, the bifidogenic activity of this substrate is still unknown. In the current study, we evaluated the ability of chitin-glucan to influence growth of 100 bifidobacterial strains belonging to those species commonly identified within the bifidobacterial communities residing in the infant and adult human gut. Such analyses were coupled with transcriptome experiments directed to explore the transcriptional effects of CG on Bifidobacterium breve 2L, which was shown to elicit the highest growth performance on this natural polysaccharide. In addition, an in vivo trial involving a rat model revealed how the colonization eff

SUBMITTER: Alessandri G 

PROVIDER: S-EPMC6453949 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature