Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F_2α-induced Contractions and Inflammatory Responses in Human Myometrium.

ABSTRACT: Oxytocin receptor antagonists (OTR-A) have been developed as tocolytics for the management of preterm labour due to the significant role of oxytocin (OT) in the onset of both term and preterm labour. Similar to OT, prostaglandins (PGs) play key roles in myometrial contractility and cervical ripening. Inhibition of PG synthesis/activity is used to delay preterm birth. Thus, targeting the PG pathway in combination with an OTR-A may be an effective strategy for delaying preterm delivery. In this study, we examined the effects of atosiban and nolasiban on PGF_2α-induced contractions and pro-inflammatory responses in human pregnant myometrium. Both OTR-As, atosiban and nolasiban, inhibited PGF_2α-induced contractions in a dose-dependent manner (p < 0.001 and p < 0.01, respec

SUBMITTER: Kim SH 

PROVIDER: S-EPMC6453954 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature