Rbpj expression in regulatory T cells is critical for restraining T_H2 responses.

ABSTRACT: The transcriptional regulator Rbpj is involved in T-helper (T_H) subset polarization, but its function in T_reg cells remains unclear. Here we show that T_reg-specific Rbpj deletion leads to splenomegaly and lymphadenopathy despite increased numbers of T_reg cells with a polyclonal TCR repertoire. A specific defect of Rbpj-deficient T_reg cells in controlling T_H2 polarization and B cell responses is observed, leading to the spontaneous formation of germinal centers and a T_H2-associated immunoglobulin class switch. The observed phenotype is environment-dependent and can be induced by infection with parasitic nematodes. Rbpj-deficient T_reg cells adopt open chromatin landscapes and gene expression profiles remi

SUBMITTER: Delacher M 

PROVIDER: S-EPMC6453958 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature