Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers.

ABSTRACT:

Background

Brain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the field of MS. In fact, MS is a complex disease and several processes can be selected as a target for PET imaging. The use of PET with several different tracers has been mainly evaluated in the research setting to investigate disease pathophysiology (i.e. phenotypes, monitoring of progression) or to explore its use a surrogate end-point in clinical trials.

Results

We have reviewed PET imaging studies in MS in humans and animal models. Tracers have been grouped according to their pathophysiological targets (ie. tracers for myelin kinetic, neuroinflammation, and

SUBMITTER: Bauckneht M 

PROVIDER: S-EPMC6453990 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature