Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury.

ABSTRACT: Introduction: Elevated levels of mitochondrial reactive oxygen species (ROS) contribute to the development of numerous cardiovascular diseases. TERT, the catalytic subunit of telomerase, has been shown to translocate to mitochondria to suppress ROS while promoting ATP production. Acute overexpression of TERT increases survival and decreases infarct size in a mouse model of myocardial infarct, while decreased telomerase activity predisposes to mitochondrial defects and heart failure. In the present study, we examined the role of TERT on cardiac structure and function under basal conditions and conditions of acute or prolonged stress in a novel rat model of TERT deficiency. Methods: Cardiac structure and function were evaluated via transthoracic echocardiogram. Langendorff prep

SUBMITTER: Ait-Aissa K 

PROVIDER: S-EPMC6454001 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature