Alzheimer and depressive cognitive-like behaviors in male and female rats: A new method for exposure to ambient air pollution.

ABSTRACT: In the previous studies regarding the effects of exposure to ambient air pollution on biological markers and/or behavior of animals, the gaseous pollutants are not separated from the particulate matter (PM). Hence the synergetic effect of gaseous pollutants and PM was not considered. In this regard, current study was aimed to devolve a new method for separation of PM from gaseous pollutants. Also, the effect of exposure to fine particulate matter (PM_2.5) on the Alzheimer and depressive cognitive-like behaviors in rats after 3 and 6 months were investigated. Three chambers were designed including exposure group 1 (PM_2.5 plus gaseous pollutants alone), exposure group 2 (gaseous pollutants alone) and control group (clean air). Exposure time was 5 h per day (9.00 a.m.-2.0

SUBMITTER: Motesaddi Zarandi S 

PROVIDER: S-EPMC6454125 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature