Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia.

ABSTRACT:

Background/objective

The number of long-term survivors of childhood acute leukemia (AL) is substantially growing. These patients are at high risk for metabolic syndrome (MS), especially those who received total body irradiation (TBI). The consequences of children's irradiation on adipose tissue (AT) development in adulthood are currently unknown. The objective of this study is to assess the impact of TBI on AT of childhood AL survivors.

Design

We compared the morphological and functional characteristics of AT among survivors of childhood AL who developed MS and received (n = 12) or not received (n = 12) TBI.

Subjects/methods

Body fat distribution and ectopic fat stores (abdominal visceral and liver fat) were evaluated by DEXA, MRI and 1H-spectroscopy. Functional chara

SUBMITTER: Visentin S 

PROVIDER: S-EPMC6454302 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature