Transcriptome and Proteome Response of Rhipicephalus annulatus Tick Vector to Babesia bigemina Infection.

ABSTRACT: A system biology approach was used to gain insight into tick biology and interactions between vector and pathogen. Rhipicephalus annulatus is one of the main vectors of Babesia bigemina which has a massive impact on animal health. It is vital to obtain more information about this relationship, to better understand tick and pathogen biology, pathogen transmission dynamics, and new potential control approaches. In ticks, salivary glands (SGs) play a key role during pathogen infection and transmission. RNA sequencing obtained from uninfected and B. bigemina infected SGs obtained from fed female ticks resulted in 6823 and 6475 unigenes, respectively. From these, 360 unigenes were found to be differentially expressed (p < 0.05). Reversed phase liquid chromatography-m

SUBMITTER: Antunes S 

PROVIDER: S-EPMC6454348 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature