Gut microbial and metabolomic profiles after fecal microbiota transplantation in pediatric ulcerative colitis patients.

ABSTRACT: Ulcerative colitis is a chronic inflammatory disease of the colon that carries a significant disease burden in children. Therefore, new therapeutic approaches are being explored to help children living with this disease. Fecal microbiota transplantation (FMT) has been successful in some children with ulcerative colitis. However, the mechanism of its therapeutic effect in this patient population is not well understood. To characterize changes in gut microbial and metabolomic profiles after FMT, we performed 16S rRNA gene sequencing, shotgun metagenomic sequencing, virome analysis and untargeted metabolomics by gas chromatography-time of flight-mass spectrometry on stool samples collected before and after FMT from four children with ulcerative colitis who responded to this treatment. Alpha d

SUBMITTER: Nusbaum DJ 

PROVIDER: S-EPMC6454419 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature