Automated Cervical Screening and Triage, Based on HPV Testing and Computer-Interpreted Cytology.

ABSTRACT:

Background

State-of-the-art cervical cancer prevention includes human papillomavirus (HPV) vaccination among adolescents and screening/treatment of cervical precancer (CIN3/AIS and, less strictly, CIN2) among adults. HPV testing provides sensitive detection of precancer but, to reduce overtreatment, secondary "triage" is needed to predict women at highest risk. Those with the highest-risk HPV types or abnormal cytology are commonly referred to colposcopy; however, expert cytology services are critically lacking in many regions.

Methods

To permit completely automatable cervical screening/triage, we designed and validated a novel triage method, a cytologic risk score algorithm based on computer-scanned liquid-based slide features (FocalPoint, BD, Burlington, NC). We compared i

SUBMITTER: Yu K 

PROVIDER: S-EPMC6454428 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature