Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness.

ABSTRACT: The hypothalamus is a central hub for regulating sleep-wake patterns, the circuitry of which has been investigated extensively in experimental animals. This work has identified a wake-promoting region in the posterior hypothalamus, with connections to other wake-promoting regions, and a sleep-promoting region in the anterior hypothalamus, with inhibitory projections to the posterior hypothalamus. It is unclear whether a similar organization exists in humans. Here, we use anatomical landmarks to identify homologous sleep- and wake-promoting regions of the human hypothalamus and investigate their functional relationships using resting-state functional connectivity magnetic resonance imaging in healthy awake participants. First, we identify a negative correlation (anticorrelation) between the

SUBMITTER: Boes AD 

PROVIDER: S-EPMC6454456 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature