The ethics of clinical applications of germline genome modification: a systematic review of reasons.

ABSTRACT:

Study question

What are the reasons for or against the future clinical application of germline genome modification (GGM)?

Summary answer

A total of 169 reasons were identified, including 90 reasons for and 79 reasons against future clinical application of GGM.

What is known already

GGM is still unsafe and insufficiently effective for clinical purposes. However, the progress made using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)- CRISPR-associated system (Cas) has led scientists to expect to overcome the technical hurdles in the foreseeable future. This has invited a debate on the socio-ethical and legal implications and acceptability of clinical applications of GGM. However, an overview of the reasons presented in this debate is missing.

Stud

SUBMITTER: van Dijke I 

PROVIDER: S-EPMC6454467 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature