A novel transcriptional network for the androgen receptor in human epididymis epithelial cells.

ABSTRACT:

Study question

What is the transcriptional network governed by the androgen receptor (AR) in human epididymis epithelial (HEE) cells from the caput region and if the network is tissue-specific, how is this achieved?

Summary answer

About 200 genes are differentially expressed in the caput HEE cells after AR activation; the AR transcriptional network is tissue-specific and may be mediated in part by distinct AR co-factors including CAAT-enhancer binding protein beta (CEBPB) and runt-related transcription factor 1 (RUNX1).

What is known already

Little is known about the AR transcriptional program genome wide in HEE cells, nor its co-factors in those cells. AR has been best studied in the prostate gland epithelium and prostate cancer cell lines, due to the important role

SUBMITTER: Yang R 

PROVIDER: S-EPMC6454485 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature