Association of dietary insulinemic potential and colorectal cancer risk in men and women.

ABSTRACT:

Background

Insulin response may be important in colorectal cancer development. Diet modulates insulin response and may be a modifiable factor in colorectal cancer prevention.

Objective

We examined associations between hyperinsulinemic diets and colorectal cancer risk with the use of an empirical dietary index for hyperinsulinemia (EDIH), a food-based index that characterizes dietary insulinemic potential on the basis of circulating C-peptide concentrations.

Design

Diet was assessed every 4 y with food-frequency questionnaires in 46,210 men (Health Professionals Follow-Up Study, 1986-2012) and 74,191 women (Nurses' Health Study, 1984-2012) to calculate EDIH scores. Multivariable-adjusted Cox regression was used to calculate HRs and 95% CIs for colorectal, proximal/dist

SUBMITTER: Tabung FK 

PROVIDER: S-EPMC6454497 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature