L1000FWD: fireworks visualization of drug-induced transcriptomic signatures.

ABSTRACT:

Motivation

As part of the NIH Library of Integrated Network-based Cellular Signatures program, hundreds of thousands of transcriptomic signatures were generated with the L1000 technology, profiling the response of human cell lines to over 20 000 small molecule compounds. This effort is a promising approach toward revealing the mechanisms-of-action (MOA) for marketed drugs and other less studied potential therapeutic compounds.

Results

L1000 fireworks display (L1000FWD) is a web application that provides interactive visualization of over 16 000 drug and small-molecule induced gene expression signatures. L1000FWD enables coloring of signatures by different attributes such as cell type, time point, concentration, as well as drug attributes such as MOA and clinical phase. Signat

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6454499 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature