Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice.

ABSTRACT:

Background

The contribution of single nucleotide polymorphisms in transcriptional regulation of the human angiotensin receptor type I (hAT1R) gene in age-related chronic pathologies such as hypertension and associated renal disorders is not well known. The hAT1R gene has single nucleotide polymorphisms in its promoter that forms 2 haplotypes (Hap), Hap-I and Hap-II. Hap-I of AT1R gene is associated with hypertension in Caucasians. We have hypothesized here that age will alter the transcriptional environment of the cell and will regulate the expression of hAT1R gene in a haplotype-dependent manner. This could likely make subjects with Hap-I increasingly susceptible to age-associated, AT1R-mediated complications.

Method

We generated transgenic (TG) mice with Hap-I and Hap-II.

SUBMITTER: Jain S 

PROVIDER: S-EPMC6454504 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature