Vitamin D Status Is Not Associated with Risk of Early Menopause.

ABSTRACT:

Background

Early natural menopause, the cessation of ovarian function before age 45 y, is positively associated with cardiovascular disease and other conditions. Dietary vitamin D intake has been inversely associated with early menopause; however, no previous studies have evaluated risk with regard to plasma 25-hydroxyvitamin D [25(OH)D] concentrations.

Objective

We prospectively evaluated associations of total and free 25(OH)D and vitamin D-binding protein (VDBP) concentrations and the risk of early menopause in a case-control study nested within the Nurses' Health Study II (NHS2). We also considered associations of 25(OH)D and VDBP with anti-Müllerian hormone (AMH) concentrations.

Methods

The NHS2 is a prospective study in 116,430 nurses, aged 25-42 y at baseline (1

SUBMITTER: Purdue-Smithe AC 

PROVIDER: S-EPMC6454521 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature