The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma.

ABSTRACT:

Background

CpG island methylator phenotype (CIMP) is found in 15-20% of malignant colorectal tumors and is characterized by strong CpG hypermethylation over the genome. The molecular mechanisms of this phenomenon are not still fully understood. The development of CIMP is followed by global gene expression alterations and metabolic changes. In particular, CIMP-low colon adenocarcinoma (COAD), predominantly corresponded to consensus molecular subtype 3 (CMS3, "Metabolic") subgroup according to COAD molecular classification, is associated with elevated expression of genes participating in metabolic pathways.

Methods

We performed bioinformatics analysis of RNA-Seq data from The Cancer Genome Atlas (TCGA) project for CIMP-high and non-CIMP COAD samples with DESeq2, clusterProfile

SUBMITTER: Fedorova MS 

PROVIDER: S-EPMC6454590 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature