Exome-wide survey of the Siberian Caucasian population.

ABSTRACT:

Background

Population structure is an important factor in the genetic association studies but often remains underexplored for many human populations. We identified exome variants in 39 Siberian Caucasian individuals from Novosibirsk, Russia and compared their genetic allele frequencies with European populations from 1000 Genomes Project.

Methods

The study participants were from Novosibirsk and represented people with monogenic diabetes, healthy individuals and a cohort from the tick-borne encephalitis study. Isolated DNA was enriched using Agilent SureSelect V5 kit and sequenced on Illumina HiSeq 4000 and genetic variants were identified using GATK pipeline. To estimate the patterns of the population structure we used PCA and ADMIXTURE analysis. Pharmocogenetically and medic

SUBMITTER: Yurchenko AA 

PROVIDER: S-EPMC6454596 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature