Subtype classification and functional annotation of L1Md retrotransposon promoters.

ABSTRACT:

Background

L1Md retrotransposons are the most abundant and active transposable elements in the mouse genome. The promoters of many L1Md retrotransposons are composed of tandem repeats called monomers. The number of monomers varies between retrotransposon copies, thus making it difficult to annotate L1Md promoters. Duplication of monomers contributes to the maintenance of L1Md promoters during truncation-prone retrotranspositions, but the associated mechanism remains unclear. Since the current classification of monomers is based on limited data, a comprehensive monomer annotation is needed for supporting functional studies of L1Md promoters genome-wide.

Results

We developed a pipeline for de novo monomer detection and classification. Identified monomers are further cla

SUBMITTER: Zhou M 

PROVIDER: S-EPMC6454616 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature