3DMMS: robust 3D Membrane Morphological Segmentation of C. elegans embryo.

ABSTRACT:

Background

Understanding the cellular architecture is a fundamental problem in various biological studies. C. elegans is widely used as a model organism in these studies because of its unique fate determinations. In recent years, researchers have worked extensively on C. elegans to excavate the regulations of genes and proteins on cell mobility and communication. Although various algorithms have been proposed to analyze nucleus, cell shape features are not yet well recorded. This paper proposes a method to systematically analyze three-dimensional morphological cellular features.

Results

Three-dimensional Membrane Morphological Segmentation (3DMMS) makes use of several novel techniques, such as statistical intensity normalization, and region filters, to pre-process the cell i

SUBMITTER: Cao J 

PROVIDER: S-EPMC6454620 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature