A specific gene expression signature for visceral organ metastasis in breast cancer.

ABSTRACT:

Background

Visceral organ metastasis is associated with poor survival outcomes in terms of metastasis free- and overall survival in breast carcinomas. Identification of a gene expression profile in tumours that selects a subpopulation of patients that is more likely to develop visceral organ metastases will help elucidate mechanisms for the development of distant metastases and could be of clinical value. With this study we aimed to determine genomic predictors that would help to distinguish breast cancer patients with more likelihood to develop visceral metastasis.

Methods

Gene expression profiling data of 157 primary tumours from breast cancer patients who developed distant metastases were analyzed and differentially expressed genes between the group of tumours with viscer

SUBMITTER: Savci-Heijink CD 

PROVIDER: S-EPMC6454625 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature