GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.

ABSTRACT:

Background

With the rapid development of the high throughput detection techniques, tumor-related Omics data has become an important source for studying the mechanism of tumor progression including breast cancer, one of the major malignancies worldwide. A previous study has shown that the G2 and S phase-expressed-1 (GTSE1) can act as an oncogene in several human cancers. However, its functional roles in breast cancer remain elusive.

Method

In this study, we analyzed breast cancer data downloaded from The Cancer Genome Atlas (TCGA) databases and other online database including the Oncomine, bc-GenExMiner and PROGgeneV2 database to identify the molecules contributing to the progression of breast cancer. The GTSE1 expression levels were investigated using qRT-PCR, immunoblotting

SUBMITTER: Lin F 

PROVIDER: S-EPMC6454633 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature