RMalign: an RNA structural alignment tool based on a novel scoring function RMscore.

ABSTRACT:

Background

RNA-protein 3D complex structure prediction is still challenging. Recently, a template-based approach PRIME is proposed in our team to build RNA-protein 3D complex structure models with a higher success rate than computational docking software. However, scoring function of RNA alignment algorithm SARA in PRIME is size-dependent, which limits its ability to detect templates in some cases.

Results

Herein, we developed a novel RNA 3D structural alignment approach RMalign, which is based on a size-independent scoring function RMscore. The parameter in RMscore is then optimized in randomly selected RNA pairs and phase transition points (from dissimilar to similar) are determined in another randomly selected RNA pairs. In tRNA benchmarking, the precision of RMscore is h

SUBMITTER: Zheng J 

PROVIDER: S-EPMC6454663 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature