Genome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle.

ABSTRACT:

Background

Gastrointestinal nematodes (GIN), liver flukes (Fasciola hepatica) and bovine lungworms (Dictyocaulus viviparus) are the most important parasitic agents in pastured dairy cattle. Endoparasite infections are associated with reduced milk production and detrimental impacts on female fertility, contributing to economic losses in affected farms. In quantitative-genetic studies, the heritabilities for GIN and F. hepatica were moderate, encouraging studies on genomic scales. Genome-wide association studies (GWAS) based on dense single nucleotide polymorphism (SNP) marker panels allow exploration of the underlying genomic architecture of complex disease traits. The current GWAS combined the identification of potential candidate genes with pathway analyses to obtain deeper insigh

SUBMITTER: May K 

PROVIDER: S-EPMC6454736 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature