Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee.

ABSTRACT:

Background

There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consideration of long-term risk. This systematic review aims to appraise the current evidence for the long-term (≥12 months) safety of common treatments for knee osteoarthritis (KOA).

Methods

Cochrane Database of Systematic Reviews, Medline and PubMed were systematically searched from 1990 to July 2017, inclusive. Inclusion criteria were 1) peer-reviewed publications investigating treatments for KOA referred to in the Australian Clinical Care Standard and/or Therapeutic Guidelines: Rheumatology 2) specifically addressing safety of the treatments 3) with ≥12 months

SUBMITTER: Charlesworth J 

PROVIDER: S-EPMC6454763 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature