Establishment of a three-dimensional model to study human uterine angiogenesis.

ABSTRACT:

Study question

Can primary human uterine microvascular endothelial cells (UtMVECs) be used as a model to study uterine angiogenic responses in vitro that are relevant in pregnancy?

Summary answer

UtMVECs demonstrated angiogenic responses when stimulated with proangiogenic factors, including sphingosine 1-phosphate (S1P), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), physiological levels of wall shear stress (WSS), human chorionic gonadotropin (hCG) and various combinations of estrogen and progesterone.

What is known already

During sprouting angiogenesis, signaling from growth factors and cytokines induces a monolayer of quiescent endothelial cells (ECs) lining the vasculature to degrade the extracellular matrix and invade the surrou

SUBMITTER: Duran CL 

PROVIDER: S-EPMC6454809 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature