Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding.

ABSTRACT: Influenza virus haemagglutinin (HA) and neuraminidase (NA) are involved in the recognition and modulation of sialic acids on the cell surface as the virus receptor. Although the balance between two proteins functions has been found to be crucial for viral fitness, the interplay between the proteins has not been well established. Herein we present evidence for interplay between influenza HA and NA, which may affect the balance between two glycoprotein functions. NA enzymatic activities against sialoglycans were promoted by the presence of HA, which is in accordance with the level of co-existing HA. Such activity enhancement was lost when the HA-receptor binding properties were abolished by low-pH treatment or by mutations at the HA receptor binding domain. Sialidase activities of NA-contain

SUBMITTER: Lai JCC 

PROVIDER: S-EPMC6455212 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature