F19. TREATMENT RESPONSE OVER THREE RANDOMIZATIONS IN THE TREATMENT OF EARLY-ONSET SCHIZOPHRENIA SPECTRUM DISORDERS STUDY (TEOSS)

ABSTRACT: Abstract

Background

We sought to characterize the trajectory of symptom change in the Treatment of Early-Onset Schizophrenia Spectrum Disorders Study (TEOSS), the largest randomized control trial in early-onset schizophrenia.

Methods

TEOSS randomized 119 youths ages 8–19 years old to 8 weeks of treatment with molindone, risperidone, or olanzapine (First Randomization). TEOSS defined treatment response as: completion of 8 weeks of treatment with the randomized antipsychotic, a Clinical Global Impression-Improvement (CGI-I) Scale score of 1(“very much improved”) or 2 (“much improved”), and a 20% reduction in symptoms on the Positive and Negative Syndrome Scale (PANSS). If participants did not respond to the initial randomized antipsychotic, participants were re-randomized t

SUBMITTER: Taylor J 

PROVIDER: S-EPMC6455514 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature