Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models.

ABSTRACT: Traumatic brain injury (TBI) has been predicted to be a predisposing factor for amyotrophic lateral sclerosis (ALS) and other neurological disorders. Despite the importance of TBI in ALS progression, the underlying cellular and molecular mechanisms are still an enigma. Here, we examined the contribution of TBI as an extrinsic factor and investigated whether TBI influences the susceptibility of developing neurodegenerative symptoms. To evaluate the effects of TBI in vivo, we applied mild to severe trauma to Drosophila and found that TBI leads to the induction of stress granules (SGs) in the brain. The degree of SGs induction directly correlates with the level of trauma. Furthermore, we observed that the level of mortality is directly proportional to the number of traumatic hits. Interesting

SUBMITTER: Anderson EN 

PROVIDER: S-EPMC6455923 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature