Resting and exercise energy metabolism in weight-reduced adults with severe obesity.

ABSTRACT:

Objective

To determine effects of physical activity (PA) with diet-induced weight loss on energy metabolism in adults with severe obesity.

Methods

Adults with severe obesity (n = 11) were studied across 6 months of intervention, then compared with controls with less severe obesity (n = 7) or normal weight (n = 9). Indirect calorimetry measured energy metabolism during exercise and rest. Markers of muscle oxidation were determined by immunohistochemistry. Data were presented as medians.

Results

The intervention induced 7% weight loss (P = 0.001) and increased vigorous PA by 24 min/wk (P = 0.02). During exercise, energy expenditure decreased, efficiency increased (P ≤ 0.03), and fatty acid oxidation (FAO) did not change. Succinate dehydrogenase increased (P = 0.001), bu

SUBMITTER: Hames KC 

PROVIDER: S-EPMC6455966 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature