A systematic review and meta-analysis of naproxen for prevention heterotopic ossification after hip surgery.

ABSTRACT:

Background

The aim of this study was to assess the efficacy of naproxen in preventing heterotopic ossification (HO) after hip surgery (total hip arthroplasty [THA] and hip arthroscopy).

Methods

Using databases (PubMed, EMBASE, and Web of Science), we conducted an electronic, systematic search of randomized controlled trials (RCTs) comparing naproxen versus placebo on HO after hip surgery. The risk ratio (RR) of the dichotomous data, weighted mean difference (WMD) of continuous data, and 95% confidence intervals (CIs) were calculated to assess the effects of naproxen in patients with hip surgery.

Results

A total of 4 studies including 269 patients were analyzed. Risk of bias was relatively high in allocation concealment and blinding. Compared with control group, admini

SUBMITTER: Zhang AH 

PROVIDER: S-EPMC6455982 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature