A Genome-Wide Association Study of Skin and Iris Pigmentation among Individuals of South Asian Ancestry.

ABSTRACT: South Asia has a complex history of migrations and is characterized by substantial pigmentary and genetic diversity. For this reason, it is an ideal region to study the genetic architecture of normal pigmentation variation. Here, we present a meta-analysis of two genome-wide association studies (GWASs) of skin pigmentation using skin reflectance (M-index) as a quantitative phenotype. The meta-analysis includes a sample of individuals of South Asian descent living in Canada (N = 348), and a sample of individuals from two caste and four tribal groups from West Maharashtra, India (N = 480). We also present the first GWAS of iris color in South Asian populations. This GWAS was based on quantitative measures of iris color obtained from high-resolution iris pictures. We identified genome-wide si

SUBMITTER: Jonnalagadda M 

PROVIDER: S-EPMC6456006 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature