Differential Rates of Change in Measures of Ovarian Reserve in Young Cancer Survivors Across the Reproductive Lifespan.

ABSTRACT:

Context

Recent studies have examined level and rate of change of anti-Müllerian hormone (AMH) for predicting time to menopause. Limited prospective, longitudinal data exists evaluating measures of ovarian reserve (MOR) in cancer survivors.

Purpose

Determine the rate of change of MOR in survivors (15 to 39 years) compared with similar-aged controls and compared with late reproductive-aged controls (40 to 50 years).

Design

Prospective cohort.

Setting

Quaternary university hospital.

Participants

Survivors at least 1 year from therapy completion, similar-aged controls, and late reproductive-aged controls.

Interventions

Annual visits with early follicular-phase hormone analysis and ultrasound.

Main outcome measure

Changes in AMH and antral folli

SUBMITTER: Cameron K 

PROVIDER: S-EPMC6456010 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature