Robust network-based analysis of the associations between (epi)genetic measurements.

ABSTRACT: With its important biological implications, modeling the associations of gene expression (GE) and copy number variation (CNV) has been extensively conducted. Such analysis is challenging because of the high data dimensionality, lack of knowledge regulating CNVs for a specific GE, different behaviors of the cis-acting and trans-acting CNVs, possible long-tailed distributions and contamination of GE measurements, and correlations between CNVs. The existing methods fail to address one or more of these challenges. In this study, a new method is developed to model more effectively the GE-CNV associations. Specifically, for each GE, a partially linear model, with a nonlinear cis-acting CNV effect, is assumed. A robust loss function is adopted to accommodate long-tailed distr

SUBMITTER: Wu C 

PROVIDER: S-EPMC6456078 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature