Outlook for tuberculosis elimination in California: An individual-based stochastic model.

ABSTRACT:

Rationale

As part of the End TB Strategy, the World Health Organization calls for low-tuberculosis (TB) incidence settings to achieve pre-elimination (<10 cases per million) and elimination (<1 case per million) by 2035 and 2050, respectively. These targets require testing and treatment for latent tuberculosis infection (LTBI).

Objectives

To estimate the ability and costs of testing and treatment for LTBI to reach pre-elimination and elimination targets in California.

Methods

We created an individual-based epidemic model of TB, calibrated to historical cases. We evaluated the effects of increased testing (QuantiFERON-TB Gold) and treatment (three months of isoniazid and rifapentine). We analyzed four test and treat targeting strategies: (1) individuals with medical ri

SUBMITTER: Goodell AJ 

PROVIDER: S-EPMC6456190 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature