Instructed Assembly as Context-Dependent Signaling for the Death and Morphogenesis of Cells.

ABSTRACT: Context-dependent signaling is a ubiquitous phenomenon in nature, but ways to mimic the essence of these nano- and microscale dynamic molecular processes by noncovalent synthesis in the cellular environment have yet to be developed. Herein we present a dynamic continuum of noncovalent filaments formed by the instructed assembly (iA) of a supramolecular phosphoglycopeptide (sPGP) as context-dependent signals for controlling the death and morphogenesis of cells. Specifically, ectophosphatase enzymes on cancer cells catalyze the formation of sPGP filaments to result in cell death; however, damping of the enzyme activity induces the formation 3D cell spheroids. Similarly, the ratio of stromal and cancer cells in a coculture can be used to modulate the expression of the ectophosphatase, so that

SUBMITTER: Wang H 

PROVIDER: S-EPMC6456411 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature