Loss of functional connectivity is an early imaging marker in primary lateral sclerosis.

ABSTRACT:

Objective

The clinical diagnosis of primary lateral sclerosis can only be made after upper motor neuron symptoms have progressed for several years without developing lower motor neuron signs. The goal of the study was to identify neuroimaging changes that occur early in primary lateral sclerosis, prior to clinical diagnosis.

Methods

MRI scans were obtained on 13 patients with adult-onset progressive spasticity for five years or less who were followed longitudinally to confirm a clinical diagnosis of primary lateral sclerosis. Resting state functional MRI, diffusion tensor imaging, and anatomical images were obtained. These "pre-PLS" patients were compared to 18 patients with longstanding, established primary lateral sclerosis and 28 controls.

Results

Pre-PLS patients

SUBMITTER: Clark MG 

PROVIDER: S-EPMC6456429 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature