Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance.

ABSTRACT: Host defenses against pathogens are energetically expensive, leading ecological immunologists to postulate that they might participate in energetic trade-offs with other maintenance programs. However, the metabolic costs of immunity and the nature of physiologic trade-offs it engages are largely unknown. We report here that activation of immunity causes an energetic trade-off with the homeothermy (the stable maintenance of core temperature), resulting in hypometabolism and hypothermia. This immunity-induced physiologic trade-off was independent of sickness behaviors but required hematopoietic sensing of lipopolysaccharide (LPS) via the toll-like receptor 4 (TLR4). Metabolomics and genome-wide expression profiling revealed that distinct metabolic programs supported entry and recovery from t

SUBMITTER: Ganeshan K 

PROVIDER: S-EPMC6456449 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature