Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations.

ABSTRACT:

Aim

Adiponectin exhibits its biological effects through adiponectin receptors (AdipoR1 and AdipoR2), which are distributed in the kidneys, and activation of those receptors could prevent or ameliorate diabetic nephropathy. This study aimed to evaluate the associations between AdipoR single nucleotide polymorphisms (SNPs) and kidney function in an elderly Japanese population.

Methods

A total of 271 elderly Japanese volunteers underwent anthropometric and laboratory tests (cystatin C-based eGFR and total and high molecular weight adiponectin levels at baseline and a follow-up visit). Genotype data were obtained for the selected 7 and 5 AdipoR1 and AdipoR2 SNPs, respectively.

Results

In a cross-sectional analysis at baseline, we found a significant association between th

SUBMITTER: Kobayashi H 

PROVIDER: S-EPMC6456456 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature