Tribo-Charging Behaviour of Inhalable Mannitol Blends with Salbutamol Sulphate.

ABSTRACT:

Purpose

The performance of carrier-based dry powder inhaler (DPI) formulations can be critically impacted by interfacial interactions driven by tribo-electrification. Therefore, the aim of the present work was to understand how distinct API particle characteristics affect the charging behaviour of blends intended for DPI delivery.

Methods

Salbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs. D-mannitol was selected as a model carrier. The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe.

Results

The spray-dried SBS (amorphous and spherical) charged positively and to a higher extent than jet mi

SUBMITTER: Zellnitz S 

PROVIDER: S-EPMC6456482 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature