Single nucleotide polymorphisms of let-7-related genes increase susceptibility to breast cancer.

ABSTRACT:

Background

Let-7 is a microRNA (miRNA) that targets the β2 adrenergic receptor (ADRB2), hypoxia inducible factor 1 subunit alpha inhibitor (HIF1AN), and claudin 12 (CLDN12) genes. Single nucleotide polymorphisms (SNPs) in the structural or regulatory regions of these miRNA let-7-related genes may be associated with breast cancer carcinogenesis and prognosis. Low let-7 expression may increase breast cancer risk. We investigated the effects of let-7-related gene SNP (mirSNPs) on breast cancer risk and clinical outcomes.

Methods

The distribution frequencies of the three SNPs were genotyped in patients with breast cancer and controls. Multivariate logistic regression analysis was used to evaluate the association between the SNPs and susceptibility to breast

SUBMITTER: Du Y 

PROVIDER: S-EPMC6456510 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature