The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients.

ABSTRACT: Cross talk occurs between the human gut and the lung through a gut-lung axis involving the gut microbiota. However, the signatures of the human gut microbiota after active Mycobacterium tuberculosis infection have not been fully understood. Here, we investigated changes in the gut microbiota in tuberculosis (TB) patients by shotgun sequencing the gut microbiomes of 31 healthy controls and 46 patients. We observed a dramatic changes in gut microbiota in tuberculosis patients as reflected by significant decreases in species number and microbial diversity. The gut microbiota of TB patients were mostly featured by the striking decrease of short-chain fatty acids (SCFAs)-producingbacteria as well as associated metabolic pathways. A classification model based on the abundance of three spe

SUBMITTER: Hu Y 

PROVIDER: S-EPMC6456665 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature