NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice.

ABSTRACT: Neuronal calcium sensor-1 (NCS-1) knockout (KO) in mice (NCS-1^-/- mice) evokes behavioral phenotypes ranging from learning deficits to avolition and depressive-like behaviors. Here, we showed that with the onset of adulthood NCS-1^-/- mice gain considerable weight. Adult NCS-1^-/- mice are obese, especially when fed a high-fat diet (HFD), are hyperglycemic and hyperinsulinemic and thus develop a diabetes type 2 phenotype. In comparison to wild type (WT) NCS-1^-/- mice display a significant increase in adipose tissue mass. NCS-1^-/- adipocytes produce insufficient serum concentrations of resistin and adiponectin. In contrast to WT littermates, adipocytes of NCS-1^-/- mice are incapable of up-regulating insulin receptor (IR) concen

SUBMITTER: Ratai O 

PROVIDER: S-EPMC6456702 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature