Multiple Epistasis Interactions Within MHC Are Associated With Ulcerative Colitis.

ABSTRACT: Successful searching for epistasis is much challenging, which generally requires very large sample sizes and/or very dense marker information. We exploited the largest Crohn's disease (CD) dataset (18,000 cases + 34,000 controls) and ulcerative colitis (UC) dataset (14,000 cases + 34,000 controls) to date. Leveraging its dense marker information and the large sample size of this IBD dataset, we employed a two-step approach to exhaustively search for epistasis. We detected abundant genome-wide significant (p < 1 × 10^-13) epistatic signals, all within the MHC region. These signals were reduced substantially when conditional on the additive background, but still nine pairs remained significant at the Immunochip-wide level (P < 1.1 × 10^-8) in conditional tes

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6456704 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature